Hi,
Recently I have been working on the "From Genes to Genetic Diseases: What Kinds of Mutations Matter?" project.
https://www.sciencebuddies.org/science- ... #procedure
I have completed it, however I am confused about what you can conclude from the data, and how you can make a graph from it. From my data, I can infer that if the normal and mutant amino acids are different, then a genetic disease occurs. This is about it, though. Any help would be greatly appreciated. Thanks!
Genetic Mutations Project
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Re: Genetic Mutations Project
To update on this, I have talked to my teacher and he has told me a graph is not necessary for this project. Could someone help me with a possible hypothesis for this?
Thanks!
Thanks!
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Re: Genetic Mutations Project
Hello hannah_tsay,
A hypothesis is a statement about what you expect to happen in your experiment. Your hypothesis should include what you will do in your experiment to make something happen that you can observe or measure. There is a great tutorial on constructing a hypothesis at this link:
https://www.sciencebuddies.org/science- ... ml#keyinfo
In the project you are working on, your hypothesis should be about the kind of amino acid sequence change that results in pathogenic alleles.
I hope this helps. Please post again if you have more questions.
A. Norman
A hypothesis is a statement about what you expect to happen in your experiment. Your hypothesis should include what you will do in your experiment to make something happen that you can observe or measure. There is a great tutorial on constructing a hypothesis at this link:
https://www.sciencebuddies.org/science- ... ml#keyinfo
In the project you are working on, your hypothesis should be about the kind of amino acid sequence change that results in pathogenic alleles.
I hope this helps. Please post again if you have more questions.
A. Norman
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Re: Genetic Mutations Project
Does this work?
I hypothesize that alleles which have an amino acid sequence change will cause cystic fibrosis.
Also, for some reason, I could not find any amino acid sequence change for non-pathogenic alleles on the website. I am researching cystic fibrosis, so this was all done under the CFTR gene.
I hypothesize that alleles which have an amino acid sequence change will cause cystic fibrosis.
Also, for some reason, I could not find any amino acid sequence change for non-pathogenic alleles on the website. I am researching cystic fibrosis, so this was all done under the CFTR gene.
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Re: Genetic Mutations Project
Hi hannah_tsay,
In your project you are investigating specific amino acid changes that result in pathogenic alleles. But the hypothesis you posted indicates than any amino acid sequence change will cause cystic fibrosis. I think your hypothesis should reflect the fact that you’re looking for certain kinds of amino acid changes.
I haven’t worked through this project but as I understand the procedure five non-pathogenic alleles are listed for you in Table 1 in the “Procedure” section. The procedure directs you to complete the table for the non-pathogenic alleles. Next, you are to make entries in Table 1 for ten pathogenic alleles using information from the website. I think the “Procedure” section has all of the information on non-pathogenic alleles that you need for the project.
I hope this helps. Please post again if you have more questions.
A. Norman
In your project you are investigating specific amino acid changes that result in pathogenic alleles. But the hypothesis you posted indicates than any amino acid sequence change will cause cystic fibrosis. I think your hypothesis should reflect the fact that you’re looking for certain kinds of amino acid changes.
I haven’t worked through this project but as I understand the procedure five non-pathogenic alleles are listed for you in Table 1 in the “Procedure” section. The procedure directs you to complete the table for the non-pathogenic alleles. Next, you are to make entries in Table 1 for ten pathogenic alleles using information from the website. I think the “Procedure” section has all of the information on non-pathogenic alleles that you need for the project.
I hope this helps. Please post again if you have more questions.
A. Norman
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Re: Genetic Mutations Project
How would I find the codon sequence change (DNA and mRNA), amino acid sequence change, and the effect for the non-pathogenic alleles?
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Re: Genetic Mutations Project
Hi hannah_tsay,
The DNA codon sequence changes for the five non-pathogenic alleles are listed in Table 1 in the procedure. To get the mRNA codon sequence changes you should follow the instructions given at step 3 just below Table 1.
Step 4 in the procedure describes how to determine the amino acid sequence change from the information in Figure 2 and the mRNA codon sequences you’ve listed in Table 1.
Instructions for finding the effect of the amino acid sequence changes are listed under the heading “Testing How the Mutation Matters”.
I hope this helps. Please post again if you have more questions.
A. Norman
The DNA codon sequence changes for the five non-pathogenic alleles are listed in Table 1 in the procedure. To get the mRNA codon sequence changes you should follow the instructions given at step 3 just below Table 1.
Step 4 in the procedure describes how to determine the amino acid sequence change from the information in Figure 2 and the mRNA codon sequences you’ve listed in Table 1.
Instructions for finding the effect of the amino acid sequence changes are listed under the heading “Testing How the Mutation Matters”.
I hope this helps. Please post again if you have more questions.
A. Norman