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Solubility of Proteins *

Time Required Long (2-4 weeks)
Prerequisites Basic introduction to chemistry
Material Availability A computer with Internet access is necessary for this project.
Cost Very Low (under $20)
Safety No issues
*Note: This is an abbreviated Project Idea, without notes to start your background research, a specific list of materials, or a procedure for how to do the experiment. You can identify abbreviated Project Ideas by the asterisk at the end of the title. If you want a Project Idea with full instructions, please pick one without an asterisk.


Some proteins are soluble in aqueous solutions and some are not. Insoluble proteins can be a problem because the proteins can form large aggregates in solution which are difficult to purify, crystallize, and use in experiments. Compare the amino acid sequence and 3-D structures of some soluble and insoluble proteins (Berman, 2000). Is the structure polar or non-polar, and how might this affect solubility? How do detergents make an insoluble protein more soluble? Investigate how this technology is used to make cleaning products that are designed to break up the biochemical particulate matter that create stains on clothing and other surfaces. Are detergents or special enzymes involved?

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Science Buddies Staff. "Solubility of Proteins" Science Buddies. Science Buddies, 30 June 2014. Web. 24 Oct. 2014 <http://www.sciencebuddies.org/science-fair-projects/project_ideas/BioChem_p018.shtml>

APA Style

Science Buddies Staff. (2014, June 30). Solubility of Proteins. Retrieved October 24, 2014 from http://www.sciencebuddies.org/science-fair-projects/project_ideas/BioChem_p018.shtml

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Last edit date: 2014-06-30


Berman, H.M., et. al., 2000. "The Protein Data Bank," Nucleic Acids Research, 28 pp. 235-242 (2000). [accessed 3/25/06] http://www.rcsb.org/pdb/Welcome.do.

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