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Science Fair Project Idea
How a biological system functions is a consequence of the 3-D structures of biological macromolecules like proteins and protein complexes. Proteins can be categorized into different protein families based upon sequence, structure, and function. Typically, proteins in the same family have similar biochemical functions. You can investigate the structure of a protein by using protein databases (Entrez Protein, SwissProt, PDB) and 3-D computational models. You can compare the structures of… Read more
BioChem_p021
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Time Required Very Long (1+ months)
Prerequisites Advanced biology course, or willingness to read up on such topics extensively.
Material Availability A computer with Internet access is necessary for this project.
Cost Very Low (under $20)
Safety No issues
Science Fair Project Idea
Some proteins are soluble in aqueous solutions and some are not. Insoluble proteins can be a problem because the proteins can form large aggregates in solution which are difficult to purify, crystallize, and use in experiments. Compare the amino acid sequence and 3-D structures of some soluble and insoluble proteins (Berman, 2000). Is the structure polar or non-polar, and how might this affect solubility? How do detergents make an insoluble protein more soluble? Investigate how this… Read more
BioChem_p018
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Time Required Long (2-4 weeks)
Prerequisites Basic introduction to chemistry
Material Availability A computer with Internet access is necessary for this project.
Cost Very Low (under $20)
Safety No issues
Science Fair Project Idea
Minerals are sometimes precious, like diamonds. But most minerals are very common, like sodium, which is found in salt. How are minerals found and identified? How are our mineral resources distributed? Visit the USGS Mineral Resource Program to find mineral resources in your state. How are satellite images used to identify potential mineral sources? You can also find out how minerals are identified using spectroscopy. How are potentially harmful minerals, like mercury, dealt with? Visit the… Read more
Geo_p026
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Time Required Average (6-10 days)
Science Fair Project Idea
How do you turn a 2-dimensional piece of paper into a 3-dimensional work of art? Origami, the classical art of Japanese paper folding, is loaded with mathematical themes and concepts. What are the common folds in origami, and how do they combine to create 3-dimensional structure? Can you classify different types of origami into classes based upon the types of folds they use? Can you show Kawasaki's Theorem, that if you add up the angle measurements of every other angle around a point, the sum… Read more
Math_p032
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Time Required Long (2-4 weeks)
Science Fair Project Idea
Unlocking the three-dimensional structure of a protein is crucial to help scientists understand how it functions in our bodies and how it can cause devastating diseases if it becomes disrupted or interacts in the wrong way. However, figuring out the structure of a protein in three-dimensional space can be very challenging. Proteins are the functional units of our cells, and every protein is made up of a long chain of amino acids. Amino acids come in different shapes and sizes, and they have… Read more
BioMed_p008
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Time Required Long (2-4 weeks)
Prerequisites Understanding of what proteins are.
Material Availability Readily available
Cost Very Low (under $20)
Safety No issues
Science Fair Project Idea
The DNA in our cells contains our "blueprints," but it's the proteins in our cells that do most of the work. The Human Genome Project has allowed us to start reading the blueprints, but we still don't understand what most of the proteins do. This is a fairly advanced project that explores ways of identifying the function of unknown proteins. Read more
Genom_p002
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Time Required Long (2-4 weeks)
Prerequisites High School Biology, excellent computer skills
Material Availability None required
Cost Very Low (under $20)
Safety No issues
Science Fair Project Idea
Research the famous collapse of the Tacoma Narrows suspension bridge. What lessons were learned about the potentially damaging effects of wind on bridges? What structures stabilize a bridge against wind forces? Build models and use a wind tunnel to test your hypothesis. Read more
Aero_p030
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Time Required Very Long (1+ months)
Science Fair Project Idea
Our forests are a very important natural resource that need to be managed wisely. We use wood products for many different purposes: building materials, paper, cardboard, furniture, fuel, etc. How can we use wood products in a sustainable manner? You can do experiments that examine the growth time of different tree species to see which are good candidates for tree farming. Which types of lumber are most sustainable? You can also compare the effects of clear cutting vs. thinning a forested… Read more
EnvSci_p038
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Time Required Long (2-4 weeks)
Science Fair Project Idea
Antibiotics work by destabilizing the metabolism or cellular structure of bacteria, preventing growth, and causing bacteria to die. Some strains of bacteria have mutated and found a way to resist the actions of antibiotics. These are called resistant strains because they resist the actions of available antibiotic treatments. There are many different types of antibiotics that are continually being developed to combat new strains of resistant bacteria. Some antibiotics work better on different… Read more
MicroBio_p021
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Time Required Long (2-4 weeks)
Prerequisites This project requires access to bacteria and antibiotics in a laboratory setting. A basic knowledge of how to work with bacteria is needed to complete this science fair project. Consult the [# ProjectGuide Name="Advanced.MicrobiologyTechniquesampTroubleshooting" Value="HtmlAnchor" HtmlText="Microbiology Techniques and Troubleshooting" #] guide for information on how to conduct microbiology experiments.
Material Availability Specialty items, like bacteria and the media to grow them on, can be ordered from [# ProjectGuide Name="Advanced.ApprovedSuppliers" Value="HtmlAnchor" HtmlText="online vendors" #] such as [# Link Name="Advanced.ApprovedSuppliers.2" Value="HtmlAnchor" HtmlText="Carolina Biological Supply Company" #].
Cost High ($100 - $150)
Safety Requires adult supervision in a laboratory setting. Use sterile technique. Read the [# ProjectGuide Name="Advanced.MicroorganismsSafetyGuide" Value="HtmlAnchor" HtmlShortTitle="true" #] before starting any experiments. [# ProjectGuide Name="Advanced.ScientificReviewCommitteeSRC" Value="HtmlAnchor" HtmlText="SRC approval" #] may be necessary.
Science Fair Project Idea
The Game of Life is the invention of the mathematician John Conway. It is a cellular automaton, consisting of a grid of squares that turn "on" or "off" depending on simple mathematical rules that involve neighboring squares. Depending on how the grid is first set up (i.e., the initial conditions), various interesting patterns appear. Can you write a Game of Life program (in JavaScript or any other computer language of your choice)? Can you think of ways to alter the rules that result in… Read more
CompSci_p030
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Time Required Average (6-10 days)
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