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Science Fair Project Idea
In order to study individual biochemical compounds like proteins, DNA, or RNA, biochemists need to know how to purify these components from a complex mixture. This is especially important for biotechnology and pharmaceutical industries, which sell purified biochemicals as reagents or drugs to consumers. Do an experiment to purify DNA, RNA, or protein from a complex mixture (for purifying DNA, see the Science Buddies project ). The source of the material can be a cell line, bacterial culture,… Read more
BioChem_p026
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Time Required Average (6-10 days)
Material Availability Most items are readily available; any specialty items needed can be ordered from [# ProjectGuide Name="Advanced.ApprovedSuppliers" Value="HtmlAnchor" HtmlText="online vendors" #].
Cost Average ($50 - $100)
Safety If bacteria or cell lines are used as the source of material for purification, [# ProjectGuide Name="Advanced.ScientificReviewCommitteeSRC" Value="HtmlAnchor" HtmlText="SRC approval" #] may be necessary. Adult supervision is recommended.
Science Fair Project Idea
thumbnail Ever used a pair of molecular scissors? Restriction enzymes are molecular scissors that cut DNA into pieces. Find out which enzymes will cut, and where by making a restriction map. Then you can figure out what will happen if you change the sequence of the DNA. Will the same enzymes still cut the new DNA sequence? Read more
BioChem_p014
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Time Required Very Short (≤ 1 day)
Prerequisites None
Material Availability Readily available
Cost Very Low (under $20)
Safety No issues
Science Fair Project Idea
Did you know that you can make a simple hygrometer (a device for measuring the relative humidity of the air) with hair? This type of hygrometer is easy to build (for instructions, see: ). Does the type of hair used in the hygrometer affect the accuracy of the results? Do some types of hair respond faster than others? Do some types of hair give a larger (or smaller) response? You could get hair samples from classmates, or a local beauty shop. Use hair samples of equal length to construct… Read more
MatlSci_p035
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Time Required Short (2-5 days)
Science Fair Project Idea
How a biological system functions is a consequence of the 3-D structures of biological macromolecules like proteins and protein complexes. Proteins can be categorized into different protein families based upon sequence, structure, and function. Typically, proteins in the same family have similar biochemical functions. You can investigate the structure of a protein by using protein databases (Entrez Protein, SwissProt, PDB) and 3-D computational models. You can compare the structures of… Read more
BioChem_p021
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Time Required Very Long (1+ months)
Prerequisites Advanced biology course, or willingness to read up on such topics extensively.
Material Availability A computer with Internet access is necessary for this project.
Cost Very Low (under $20)
Safety No issues
Science Fair Project Idea
thumbnail How do scientists "copy" DNA? They use a process called the Polymerase Chain Reaction, or PCR. The key to making this process work is having a short piece of DNA, called a primer, that will stick to the larger piece of DNA you want to copy, called a template. In this science project, you will test how the number of matches and mismatches in a primer will affect its ability to stick, or anneal, to the DNA template during PCR. Read more
BioChem_p017
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Time Required Very Short (≤ 1 day)
Prerequisites None
Material Availability A large number of magnets are needed.
Cost Low ($20 - $50)
Safety No issues
Science Fair Project Idea
Soil may look like a bunch of dirt, but good quality soil is actually a complex mixture of dirt, nutrients, microorganisms, insects and worms. What type of benefit do these microorganisms offer a growing plant? You can test this by baking soil in the oven to sterilize and kill the microorganisms. Do plants grown in sterile soil do better than plants in unsterilized soil? What about adding worms to one plant, but not to the other. Will the plant with worms grow better? Some insects are bad… Read more
PlantBio_p031
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Time Required Very Long (1+ months)
Prerequisites None
Material Availability Readily available
Cost Very Low (under $20)
Safety Adult supervision is required when using the oven. Use caution when handling and disposing of mold. Treat molds according to the same safety rules as outlined for bacteria in the [# ProjectGuide Name="Advanced.MicroorganismsSafetyGuide" Value="HtmlAnchor" HtmlShortTitle="true" #].
Science Fair Project Idea
Is soil structure an important factor in earthquake dynamics? Investigate soil liquefaction and how different soil types respond to earthquake movements. Are movements more dramatic in sandy/loamy or clay type soils? Which soil structures are most stable? Which are the most volatile? (MCEER, 2005) Read more
Geo_p037
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Time Required Average (6-10 days)
Science Fair Project Idea
Can you imagine Valentine's Day or Halloween without chocolate? Well, if you're a chocolate lover brace yourself for the bad news. According to the United States Department of Agriculture (USDA), "Worldwide demand for cacao now exceeds production." If there isn't enough cacao, the major raw ingredient for chocolate, then the chocolate supply will dwindle. Hang on! Before you start rushing to the store to buy all the chocolate you can get your hands on, a solution is already in the works. In… Read more
Genom_p021
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Time Required Long (2-4 weeks)
Prerequisites A high school level introductory biology course is a prerequisite for this science project.
Material Availability Readily available
Cost Very Low (under $20)
Safety No issues
Science Fair Project Idea
It is important to ensure that we all have good clean water to drink that is not contaminated by heavy metals or chemicals. One common pollutant in a water supply is lead in old pipes or paints that can leach into the water and cause lead poisoning. There are different kits available for testing the presence of lead and other contaminants in water. Test your water supply, and also the water in some local ponds, lakes or streams. The same contaminants that can harm you can also harm wildlife. … Read more
EnvSci_p024
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Time Required Average (6-10 days)
Science Fair Project Idea
You may know Lewis Carroll as the author of Alice in Wonderland, but did you know that in real life he was a mathematician who studied symbolic logic and logical reasoning? How can math help you solve Lewis Carroll's Logic Game? (Bogomolny, 2006) How are algorithms for solving the game Sudoku similar to solving a logic problem? (Hayes, 2006) For the super-advanced mathematical genius, try to evaluate currently available, logic-based computational tools, or design a better one!… Read more
Math_p035
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Time Required Average (6-10 days)
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