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Others Like “Foldit: Playing a Game While Solving Protein Structures”

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Science Fair Project Idea
Scientists recently found that some small drugs can stop infection by the deadly Ebola virus in its tracks. Lab researchers found that these drugs bind to a protein that the Ebola virus uses to enter our cells, and this is how infection is prevented. However, this also means that the bound protein no longer functions in our cells. How might these drugs accidentally disrupt important biological processes in our bodies? What other proteins might these drugs bind to? In this science project,… Read more
BioMed_p011
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Time Required Short (2-5 days)
Prerequisites Basic understanding of what viruses, drugs, genes, and proteins are.
Material Availability Readily available
Cost Very Low (under $20)
Safety No issues
Science Fair Project Idea
Can computer games be used to educate? Pick a game that incorporates educational material. There are a variety of educational computer games on the market in the areas of math, history, science, and language, as well as many simpler versions free on the Internet. Make up a test based on the subject area covered by the computer game. Have your volunteers take the test before and after playing the game. Does playing the computer game improve people's score on the test? Read more
Games_p006
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Time Required Average (6-10 days)
Prerequisites None
Material Availability Readily available
Cost Very Low (under $20)
Safety No issues
Science Fair Project Idea
How a biological system functions is a consequence of the 3-D structures of biological macromolecules like proteins and protein complexes. Proteins can be categorized into different protein families based upon sequence, structure, and function. Typically, proteins in the same family have similar biochemical functions. You can investigate the structure of a protein by using protein databases (Entrez Protein, SwissProt, PDB) and 3-D computational models. You can compare the structures of… Read more
BioChem_p021
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Time Required Very Long (1+ months)
Prerequisites Advanced biology course, or willingness to read up on such topics extensively.
Material Availability A computer with Internet access is necessary for this project.
Cost Very Low (under $20)
Safety No issues
Science Fair Project Idea
Some proteins are soluble in aqueous solutions and some are not. Insoluble proteins can be a problem because the proteins can form large aggregates in solution which are difficult to purify, crystallize, and use in experiments. Compare the amino acid sequence and 3-D structures of some soluble and insoluble proteins (Berman, 2000). Is the structure polar or non-polar, and how might this affect solubility? How do detergents make an insoluble protein more soluble? Investigate how this… Read more
BioChem_p018
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Time Required Long (2-4 weeks)
Prerequisites Basic introduction to chemistry
Material Availability A computer with Internet access is necessary for this project.
Cost Very Low (under $20)
Safety No issues
Science Fair Project Idea
Whipped egg whites are used in many sweet and savory recipes. They are used to add air into cake batters, meringues, and soufflés. Egg whites, also known as albumin are 15 percent protein dissolved into water. When egg whites are beaten or whipped, the protein chains unravel. This is called denaturation. The process of whipping egg whites adds air to the mixture, in addition to denaturing the proteins. The denatured proteins create bonds with each other and trap air bubbles within… Read more
FoodSci_p036
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Time Required Short (2-5 days)
Prerequisites None
Material Availability Readily available
Cost Low ($20 - $50)
Safety No issues
Science Fair Project Idea
Is soil structure an important factor in earthquake dynamics? Investigate soil liquefaction and how different soil types respond to earthquake movements. Are movements more dramatic in sandy/loamy or clay type soils? Which soil structures are most stable? Which are the most volatile? (MCEER, 2005) Read more
Geo_p037
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Time Required Average (6-10 days)
Science Fair Project Idea
Math can make you money! If you understand some basic math, you can make good decisions about how to keep, spend, and use your hard earned dollars. Try an experiment comparing the same balance in different types of bank accounts. How much better is a savings account than a checking account? What difference does the interest rate make? Which is better, an account that earns compound or simple interest? Can you compare the short and long term costs of borrowing money compared to saving the cash… Read more
Math_p027
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Time Required Short (2-5 days)
Science Fair Project Idea
How is geology important for our energy resources? Coal, oil, and natural gas are formed by geological processes over millions of years. Certain geological formations can indicate a reservoir of coal, oil, or natural gas. Also, geothermal processes can be used as an energy resource. How are these formations identified? How are the resources extracted? You can use the to access, view, and download information from geospatial databases containing a broad spectrum of data produced by the… Read more
Geo_p025
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Time Required Long (2-4 weeks)
Science Fair Project Idea
Many proteins act as catalysts which speed up or regulate a biochemical reaction. The kinetics of an enzyme can be investigated by measuring the reactants and products of the reaction over time. Research the enzymatic reaction of a protein and investigate its kinetics. Measure the production of hydrogen peroxide (H2O2) by catalase, the digestion of gelatin by papain, or any other enzymatic reaction you have access to. Bio-Rad's provides a great measurement platform for exploring… Read more
BioChem_p019
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Time Required Long (2-4 weeks)
Prerequisites Should have basic knowledge of chemistry and chemical reactions.
Material Availability Readily available
Cost Low ($20 - $50)
Safety Use caution when choosing a biochemical reaction to study. For more information about chemical safety, consult the [# ProjectGuide Name="Advanced.ChemistrySafetyGuide" Value="HtmlAnchor" #] Guide.
Science Fair Project Idea
Some sequences of RNA can catalyze biochemical reactions, much like protein enzymes. These catalytic RNA sequences are called ribozymes. The function of a ribozyme depends upon the primary sequence of the RNA which folds into a 3-D structure. How do different ribozyme sequences fold? You can search for ribozyme sequences using Entrez BLAST (NCBI, 2006). Then you can use a program like MFOLD () to submit your sequence for an analysis of its predicted 3-D structures based upon thermodynamics… Read more
BioChem_p023
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Time Required Very Long (1+ months)
Prerequisites Advanced biology course, or willingness to read up on such topics extensively.
Material Availability A computer with Internet access is necessary for this project.
Cost Very Low (under $20)
Safety No issues
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