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Some sequences of RNA can catalyze biochemical reactions, much like protein enzymes. These catalytic RNA sequences are called ribozymes. The function of a ribozyme depends upon the primary sequence of the RNA which folds into a 3-D structure. How do different ribozyme sequences fold? You can search for ribozyme sequences using Entrez BLAST (NCBI, 2006). Then you can use a program like MFOLD (http://bioweb.pasteur.fr/seqanal/interfaces/mfold-simple.html) to submit your sequence for an…
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Over time, viruses evolve. Their evolution is influenced by both neutral drift, the natural mutation rate of the virus, and selective pressure from the hosts' immune systems. Scientists study a virus's genomic evolution—the changes at the nucleotide and amino acid level—to better understand how the virus is spreading and the clinical implications. You can use public databases and tools to do the same type of tracking and analysis of COVID-19 that scientists around the world do. …
When you take medicine, it needs to dissolve in order to be passed into your bloodstream to have an effect. On the other hand, the drug needs to be packed into a small, dense pill to make it easier to swallow. How does the delivery method of a drug change how quickly it enters the bloodstream? Compare different brands of a drug to find out which brands dissolve the quickest. Does the pH of the stomach (which is usually between 1 and 2) matter? Compare coated to uncoated pills: does the coating…
Nut clusters, chocolate-dipped candies, and chocolate-dipped strawberries are just some of the delicious goodies that have a thin, rich layer of chocolate wrapped around them. But how do pastry and candy chefs make these delectable treats? The first step is to melt and temper chocolate. Tempering is a process in which the cocoa butter in chocolate is hardened into a specific crystalline pattern. When the cocoa butter molecules are in this pattern, the chocolate is shiny and breaks with a sharp…
Animals come in all shapes and sizes, even humans. You can look up different statistics about different kinds of animals using the Internet: average body size, brain size, life expectancy and generation time are some examples. Is there a correlation between body size and life span? Is there a correlation between body size and brain size? Is there a correlation between body size and generation time? Is there a correlation between body size and the size of your footprint? (Comparative Mammalian…
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Unlocking the three-dimensional structure of a protein is crucial to help scientists understand how it functions in our bodies and how it can cause devastating diseases if it becomes disrupted or interacts in the wrong way. However, figuring out the structure of a protein in three-dimensional space can be very challenging. Proteins are the functional units of our cells, and every protein is made up of a long chain of amino acids. Amino acids come in different shapes and sizes, and they have…
What is expression cloning and how is it used in the biotechnology industry? How are plasmids constructed for use in a bacterial expression system? You can investigate these questions and more using bacterial expression kits meant for high school classes. You will need a laboratory space equipped to grow bacteria and carry out simple molecular biology. A kit with plasmids and bacterial cells to transform are also needed. Here are two possibilities:
BioBuilder What a Colorful World Kit …
Have you ever bitten into a beautiful golden-brown cookie only to realize in dismay that the bottom is burned and black? What causes that uneven baking? Can it be prevented? You can discover the answer by conducting a science fair project to determine whether different types of cookie sheets result in noticeably different cookies. First you'll need to do some background research to figure out what kinds of baking sheets you can buy. For example, there are aluminum, steel, insulated, and…
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Mushrooms are not plants, but are fungi. Fungi include mushrooms, molds, and lichen. They do not produce seeds to reproduce like some plants. Fungi produce spores, like more primitive plants do. The spores of a mushroom are contained in the tiny folds around the stem underneath the mushroom cap. Different species of mushrooms have different types of spores, with different colors and different patterns of folds. You can make mushroom prints by removing the stem from a mushroom and placing the…
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Reclaimed (treated) wastewater can be used for many purposes, including landscape watering and freeing up valuable fresh water for other purposes (like drinking water). It's a great way to conserve water, but is it really safe? This science fair project is designed to find out.
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