candyswift23
Posts: 3
Joined: Sun May 08, 2016 8:55 pm
Occupation: Student

About sdAb

Postby candyswift23 » Sun May 08, 2016 9:03 pm

What do you know about single domain antibody (sdAb)? What are the differences between sdAb and common antibodies?

violajsilver
Posts: 5
Joined: Sun May 08, 2016 9:12 pm
Occupation: Other Adult

Re: About sdAb

Postby violajsilver » Sun May 08, 2016 10:34 pm

A single-domain antibody is an antibody fragment consisting of a single monomeric variable antibody domain. Like a whole antibody, it is able to bind selectively to a specific antigen. With a molecular weight of only 12–15 kDa, single-domain antibodies are much smaller than common antibodies (150–160 kDa) which are composed of two heavy protein chains and two light chains, and even smaller than Fab fragments (~50 kDa, one light chain and half a heavy chain) and single-chain variable fragments (~25 kDa, two variable domains, one from a light and one from a heavy chain).


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