aplastic bone marrow
Posted: Mon May 15, 2006 3:18 am
A child was brought to the hospital suffering from an aplastic bone marrow(such bone marrow cannot generate normal blood cells anymore) after ingestion of benzene. All blood elements were at low levels and death was imminent. The child and a sibling were rapidly typed as both being A+ Rh+ HLA-A3,7; HLA-B4,8; HLA-C2,9, and bone marrow was transfused. Within a few days the RBC count rose, indicating a successful take.
However, 3 weeks later the child began to experience diarrhea and a skin rash on the palms and soles of the feet, spreading to the trunk. This was followed by jaundice and enlarged liver and spleen. Administration of anti-CD3 serum plus cyclosporine produced some improvement. Eventually, the child died.
What went wrong and why
However, 3 weeks later the child began to experience diarrhea and a skin rash on the palms and soles of the feet, spreading to the trunk. This was followed by jaundice and enlarged liver and spleen. Administration of anti-CD3 serum plus cyclosporine produced some improvement. Eventually, the child died.
What went wrong and why