Science Buddies: "Ask an Expert"

how would these longevity enhancements work in humans is it likely that our lifespans would extend to the same percentage equivalent in humans. also would these add up, I realize that one's that interact like ones that extend lifespan by decreasing igf1 wouldn't necessarily interact to add up but would something like fgf21 and clearness of senescence cells add up

fgf21 over expression immune system boost and 40% mouse life extension
clearing of senescent cells that hurt the tissue environment is a 35% boost
methionine restriction is autophagy and mitochondria maintenance is a 35 % increase
in all it is a 75 or 110% (with methionine restriction) lifespan extension, is this likely to add up to 75 or 110% in humans aswell.

Human longevity is the outcome of a complex interaction of genetics, environment and lifestyle. Experiments on non-human subjects like mice do not necessarily translate to humans.

Are you planning to do a science project on aging?

I would like to, but it's probably far off because I would like to genetically engineer mice so it's not the kind of project that a current high school senior has the money to do, so I am trying to figure out the best strategy to attack it and hopefully get the best result.