Science Buddies: "Ask an Expert"

Does ADP allosterically activate or inhibit pyruvate kinase in Glycolysis? Or does it play a role in the allosteric regulation? If so, how?

I know that ATP activates pyruvate kinase, but I cannot find the regulatory effect of ADP on pyruvate kinase anywhere in my textbook nor in scientific literature. Please help me in understanding the regulatory role of ADP on pyruvate kinase in glycolysis.
Thank you very much.

Hello,

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