I think you can find information on the internet on how to make and extract of mayana, also known as Makandi, and Coleus forskohlii
- some use the leaves, others use the root.
I think you need access to some fairly sophisticated lab equipment and a local chemistry teacher or professor to actually identify the organic chemical compounds.
The web site below is commercial, so I would not take the medicinal claims to be factual, but it has some information on the active compound. There will be many compounds when you make a simple extract by crushing the plant in water or oil.
http://www.mothernature.com/Library/Enc ... /2071003#6
Active constituents: Forskolin, a chemical found in coleus, activates the enzyme adenylate cyclase.2 This enzyme is a turnkey compound that initiates a cascade of critical events within every cell of the body. Adenylate cyclase and the chemicals it activates comprise a “second messenger� system that is responsible for carrying out the complex and powerful effects of hormones in the body. Stimulation of the second messenger system by forskolin leads to blood vessel dilation,3 inhibition of allergic reactions,4 and an increase in thyroid hormone secretion.5 Forskolin has other properties as well, including inhibition of the pro-inflammatory substance known as platelet-activating factor (PAF)6 and inhibition of the spread of cancer cells.7
Studies in healthy humans, including at least one double-blind trial, have shown that direct application of an ophthalmic preparation of forskolin to the eyes lowers eye pressure,8 9 thus reducing the risk of glaucoma. Direct application of the whole herb to the eyes has not been studied and is not recommended.
Forskolin may help dilate blood vessels and improve the forcefulness with which the heart pumps blood. A preliminary trial found that forskolin reduced blood pressure and improved heart function in people with cardiomyopathy.10 It is unknown if oral coleus extracts would have the same effect. A small double-blind trial found that inhaled forskolin could decrease lung spasms in asthmatics.11 It is unclear if oral ingestion of coleus extracts will provide similar benefits.
How much is usually taken? Coleus extracts standardized to 10 to 18% forskolin are available. While some doctors expert in herbal medicine recommend 50–100 mg two to three times per day of standardized coleus extract, these amounts are extrapolations and have yet to be confirmed by direct clinical research.12 Most studies have used injected forskolin, so it is unclear if oral ingestion of coleus extracts will provide similar benefits in the amounts recommended above. Until ophthalmic preparations of coleus or forskolin are available, people with glaucoma should consult with a skilled healthcare practitioner to obtain a sterile fluid extract for use in the eyes.
what chemical substance that have the mayana and kalabo have?where can we find some samples of this kind of problems?can you help us to make some examples of literature or biography of our subject?can you make a conclusion an analysis?we hope that you help us to prove this kind of research problem.