Science Buddies: "Ask an Expert"

How do I find non-pathogenic alleles of the SNCA gene? This is for a variation of this site's experiment "From Genes to Genetic Diseases: What Kinds of Mutations Matter?"
I can't find any and would love it if you gave one to me but if not just to point me in the right direction. A fast response would be greatly appreciated.

Sincerely,
Connor.

[Administrator note: Project: https://www.sciencebuddies.org/science- ... -mutations ]

Hello!

There's an online genome database called gnomAD that might be helpful to you. I went to the website and searched "SNCA." The page I linked below is the page that comes up for the SNCA gene. Under "ClinVar variants" you can uncheck all the boxes except the box next to "Benign/likely benign." Those should be the non-pathogenic alleles. If you scroll down a little more on the page, you can click on the Variant ID for the alleles that say "Benign" under the "Clinical Significance" column. That should give you some more information on them.
https://gnomad.broadinstitute.org/gene/ ... nomad_r2_1

Let us know if you have more questions!