Active compounds against Alzheimer's disease: New insights thanks to simulations

Various molecules have been synthesized that inhibit self-assembly of the amyloid beta peptide in vitro. This peptide is strongly linked to Alzheimer's disease. Based on computer simulations, biochemists from the University of Zurich have recently shown how the active compounds and fragments of this disease-causing peptide interact with each other: it is the disordered structure of the peptide that determines the interactions with active compounds. Read more