A small cut with a big impact

During inflammation, controlled gene expression is necessary in order to allow the organism to mount an effective defense response. For this process, the protein ARTD1 is removed from the DNA. Veterinary biochemists and molecular biologists from the University of Zurich have now elucidated this previously unclear mechanism: ARTD1 is cut into two pieces by molecular scissors, which enhances gene expression. The results are groundbreaking for our understanding of inflammatory responses and the development of new anti-inflammatory drugs. Read more