Science Fair project on Schizophrenia

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deleted-228597
Posts: 5
Joined: Wed Sep 17, 2014 8:52 am
Occupation: Student: 12th grade
Project Question: Can reversing hormones in the brain reverse the effect of Schizophrenia?
Project Due Date: March 2014
Project Status: I am conducting my research

Science Fair project on Schizophrenia

Post by deleted-228597 »

Research on Schizophrenia now indicates that a deletion of a region on Chromosome 22 "22q11.2" is now the strongest link between Schizophrenia and even Autism.http://sfari.org/news-and-opinion/news/ ... izophrenia DiGeorge syndrome is the syndrome known for the syndrome caused by Chromosome 22 region "22q11.2" and causes several other effects in the body.
http://www.mayoclinic.org/diseases-cond ... n-20031464

Does having DiGeorge Syndrome automatically guarantee that you will have Schizophrenia?
sunmoonstars
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Posts: 424
Joined: Fri Dec 12, 2008 3:47 pm
Occupation: Platform Manager - Biologics
Project Question: n/a
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Project Status: Not applicable

Re: Science Fair project on Schizophrenia

Post by sunmoonstars »

Hi,

I do not belive that having DiGeorge Syndrome will mean the person also have schizophrenia. What the information means is that both conditions show some relation to the same portion of the chromosome. What it doesn't say specifically, but we understand to be true in general: 1- the chromosome location houses more than one gene, so the problem for the conditions could relate to different genes at the same location, 2- commonalities among patients (problem in specific locus), does not equal causation, meaning the genetic change there has not been proven to be the cause of the condition (it could be a coincidence, etc.), and 3- come disease states are caused by complex interactions among genes, and a problem with ONE gene is often not enough to cause a complex disease.

I hope this helps.

Tonya
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