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Solubility of Proteins

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Areas of Science
Time Required
Long (2-4 weeks)
Basic introduction to chemistry
Material Availability
A computer with Internet access is necessary for this project.
Very Low (under $20)
No issues
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Some proteins are soluble in aqueous solutions and some are not. Insoluble proteins can be a problem because the proteins can form large aggregates in solution which are difficult to purify, crystallize, and use in experiments. Compare the amino acid sequence and 3-D structures of some soluble and insoluble proteins (Berman, 2000). Is the structure polar or non-polar, and how might this affect solubility? How do detergents make an insoluble protein more soluble? Investigate how this technology is used to make cleaning products that are designed to break up the biochemical particulate matter that create stains on clothing and other surfaces. Are detergents or special enzymes involved?


Berman, H.M., et. al., 2000. "The Protein Data Bank," Nucleic Acids Research, 28 pp. 235-242 (2000). [accessed 3/25/06] http://www.rcsb.org/pdb/Welcome.do.
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General citation information is provided here. Be sure to check the formatting, including capitalization, for the method you are using and update your citation, as needed.

MLA Style

Science Buddies Staff. "Solubility of Proteins." Science Buddies, 28 July 2017, https://www.sciencebuddies.org/science-fair-projects/project-ideas/BioChem_p018/biotechnology-techniques/solubility-of-proteins. Accessed 5 June 2023.

APA Style

Science Buddies Staff. (2017, July 28). Solubility of Proteins. Retrieved from https://www.sciencebuddies.org/science-fair-projects/project-ideas/BioChem_p018/biotechnology-techniques/solubility-of-proteins

Last edit date: 2017-07-28
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