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High School, Pandemics – COVID-19 Projects, Lessons, Activities (20 results)

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The Importance of Making Sure a Drug's Aim Is True
Science Fair Project Idea
Scientific Method
Scientists recently found that some small drugs can stop infection by the deadly Ebola virus in its tracks. Lab researchers found that these drugs bind to a protein that the Ebola virus uses to enter our cells, and this is how infection is prevented. However, this also means that the bound protein no longer functions in our cells. How might these drugs accidentally disrupt important biological processes in our bodies? What other proteins might these drugs bind to? In this science project,… Read more
Tracking COVID-19's Genomic and Clinical Evolution
Science Fair Project Idea
Scientific Method
Over time, viruses evolve. Their evolution is influenced by both neutral drift, the natural mutation rate of the virus, and selective pressure from the hosts' immune systems. Scientists study a virus's genomic evolution—the changes at the nucleotide and amino acid level—to better understand how the virus is spreading and the clinical implications. You can use public databases and tools to do the same type of tracking and analysis of COVID-19 that scientists around the world do. … Read more
Can Herd Immunity Combat Viral Epidemics like COVID-19?
Science Fair Project Idea
Scientific Method
One strategy you may have heard suggested for dealing with the COVID-19 epidemic is to let nature take its course and let COVID-19 infect enough of the population for us to reach the herd immunity threshold. Does this make sense as a public health strategy? You can explore this question scientifically using SimPandemic, a free online tool for modeling infectious disease outbreaks. Before you begin, you will need to know a bit about herd immunity. Herd immunity, sometimes called community… Read more
Comparing COVID-19 Variants: A Real-World Look at the Effect of Mutations
Lesson Plan Grade: 6th-12th
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We hear about COVID-19 variants all the time, but what is a virus variant, how do they come about, and why do they matter? Students will explore these question and more in this lesson plan. They will use SimPandemic, a free online tool, to model what COVID-19 outbreaks look like when communities are exposed to different COVID-19 variants and understand how genetic mutations in a virus can lead to functional changes. Read more
NGSS Performance Expectations:
  • MS-LS2-4. Construct an argument supported by empirical evidence that changes to physical or biological components of an ecosystem affect populations.
  • MS-LS3-1. Develop and use a model to describe why structural changes to genes (mutations) located on chromosomes may affect proteins and may result in harmful, beneficial, or neutral effects to the structure and function of the organism.
  • HS-LS3-2. Make and defend a claim based on evidence that inheritable genetic variations may result from (1) new genetic combinations through meiosis, (2) viable errors occurring during replication, and/or (3) mutations caused by environmental factors.
Foldit: Playing a Game While Solving Protein Structures
Science Fair Project Idea
Scientific Method
Unlocking the three-dimensional structure of a protein is crucial to help scientists understand how it functions in our bodies and how it can cause devastating diseases if it becomes disrupted or interacts in the wrong way. However, figuring out the structure of a protein in three-dimensional space can be very challenging. Proteins are the functional units of our cells, and every protein is made up of a long chain of amino acids. Amino acids come in different shapes and sizes, and they have… Read more
How Can Vaccines Be Used to Fight Outbreaks?
Science Fair Project Idea
Scientific Method
Stopping a viral outbreak like COVID-19 takes more than luck, it takes public health tools. Vaccines are considered to be one of the best public health tools, which is why there is often a rush to develop good vaccines for newly discovered viruses, particularly those that have the potential to infect lots of people. Recent examples include COVID-19, Zika virus, and Ebola. If enough people are vaccinated, an effective vaccine can help stop outbreaks or even eradicate (completely get rid of) a… Read more
How R Naught (R₀) Shapes an Epidemic
Lesson Plan Grade: 6th-12th
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What is R naught (R₀), what factors influence it, and how does it shape the infection curves of an epidemic? Students will explore these questions and more in this lesson plan. They will then use SimPandemic, a free online tool, to model what a COVID-19 outbreak looks like in communities with different R₀ values. Remote learning adaptation: This lesson plan can be conducted remotely. Students can work independently on the Explore section of the lesson plan using the Student… Read more
NGSS Performance Expectations:
  • MS-LS2-4. Construct an argument supported by empirical evidence that changes to physical or biological components of an ecosystem affect populations.
  • HS-LS2-8. Evaluate evidence for the role of group behavior on individual and species' chances to survive and reproduce.
Model How R naught (R₀) Shapes an Epidemic
Science Fair Project Idea
Scientific Method
Even during a global pandemic like COVID-19, there are differences in how the epidemic unfolds within communities. Some communities see early, large waves of infected individuals, while others see smaller numbers of infections over a longer period of time, and others may not appear to have an epidemic at all. Could R₀ (pronounced R naught), account for some of this variation? R₀, the basic reproduction number of a disease, quantifies how many people, on average, an infected… Read more
Seasonal Disease Outbreaks
Science Fair Project Idea
Scientific Method
"Flu season" is something we deal with every winter. Cyclical or seasonal outbreaks of an infectious disease can occur for a variety of reasons, such as seasonal changes in host behavior (for example, more people staying indoors), the seasonal abundance of disease carriers (for example, mosquitos), and many others. Another factor that can play a role in cyclical outbreaks occurs when the natural immunity to a disease has a short duration. This enables each individual in the population to… Read more
Using Vaccines to Fight Outbreaks
Lesson Plan Grade: 6th-12th
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What exactly is a vaccine? Can vaccines prevent outbreaks? How effective does a vaccine need to be to help a population during an outbreak? Students will explore these questions and more in this lesson plan by first learning the biology behind vaccines. They will then use SimPandemic, a free online tool, to model different vaccine parameters to understand how vaccines affect both individuals and populations during a COVID-19 outbreak. Remote learning adaptation: This lesson plan can be… Read more
NGSS Performance Expectations:
  • MS-LS2-1. Analyze and interpret data to provide evidence for the effects of resource availability on organisms and populations of organisms in an ecosystem.
  • MS-LS2-4. Construct an argument supported by empirical evidence that changes to physical or biological components of an ecosystem affect populations.
  • HS-LS2-8. Evaluate evidence for the role of group behavior on individual and species' chances to survive and reproduce.
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