High School, Genetics & Genomics Projects, Lessons, Activities (Page 2)

From Prokaryotes to Eukaryotes: Solving Problems Using Plasmids

Lesson Plan Grade: 9th-12th

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This lesson compares and contrasts prokaryotic and eukaryotic cells and examines the form and function of the plasmid found in prokaryotic cells. Students will then use these principles to simulate how a desirable gene can be isolated and inserted into a plasmid as one step in the process of creating a genetically modified organism (GMO). Read more

NGSS Performance Expectations:

HS-LS1-2. Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms.

How Much DNA Can You Pack into a Cell?

Science Fair Project Idea

Scientific Method

Have you ever tried to pack a suitcase? If so, you know that no matter how hard you try, there is a limit to the amount you can cram in, which means if you have more stuff, you need a bigger suitcase! Do you think the same principle applies to DNA in a cell? Does an animal with a bigger genome need a larger cell nucleus to store its DNA? Try this science project and find out! Read more

The Importance of Making Sure a Drug's Aim Is True

Science Fair Project Idea

Scientific Method

Scientists recently found that some small drugs can stop infection by the deadly Ebola virus in its tracks. Lab researchers found that these drugs bind to a protein that the Ebola virus uses to enter our cells, and this is how infection is prevented. However, this also means that the bound protein no longer functions in our cells. How might these drugs accidentally disrupt important biological processes in our bodies? What other proteins might these drugs bind to? In this science project,… Read more

The Tree of Life — I (basic)

Science Fair Project Idea

Scientific Method

Imagine that a biologist arrived at your big family reunion and had no idea who were sisters, cousins, aunts, uncles, etc., but tried to sort it out by how all of you look. Just based on how you look, would s/he be able to guess whether the kid standing next to you is your sister or your cousin? The biologist might be able to make some good guesses this way, but by using samples of your family's DNA, s/he could construct your whole family tree. In this project, you'll use a Web-based… Read more

Tracking COVID-19's Genomic and Clinical Evolution

Science Fair Project Idea

Scientific Method

Over time, viruses evolve. Their evolution is influenced by both neutral drift, the natural mutation rate of the virus, and selective pressure from the hosts' immune systems. Scientists study a virus's genomic evolution—the changes at the nucleotide and amino acid level—to better understand how the virus is spreading and the clinical implications. You can use public databases and tools to do the same type of tracking and analysis of COVID-19 that scientists around the world do. … Read more

Use DNA Sequencing to Trace the Blue Whale's Evolutionary Tree

Science Fair Project Idea

Scientific Method

The first land animals took their tentative steps out of the ocean and onto solid ground around 365 million years ago. Over millions of years, these early ancestors developed into tetrapods, including amphibians, reptiles, dinosaurs, birds, and mammals. Then, around 50 million years ago, the reverse process occurred: the mammalian ancestor of today's whales returned to the ocean. In this genomics science fair project, you will use mitochondrial protein sequencing to trace the evolution of… Read more

What is the Woolly Mammoth's Closest Living Relative?

Science Fair Project Idea

Scientific Method

Woolly mammoths shook the ground of ice-age tundras for millennia, living next to saber tooth tigers and prehistoric man. Although they have been extinct for thousands of years, scientists continue to learn more and more about this mighty animal. Some of the most exciting new research is being produced by looking at DNA extracted from the hair and bones of woolly mammoths entombed in ice. In this genomics science fair project, you will use bioinformatics tools to determine the woolly mammoth's… Read more

Comparing COVID-19 Variants: A Real-World Look at the Effect of Mutations

Lesson Plan Grade: 6th-12th

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We hear about COVID-19 variants all the time, but what is a virus variant, how do they come about, and why do they matter? Students will explore these question and more in this lesson plan. They will use SimPandemic, a free online tool, to model what COVID-19 outbreaks look like when communities are exposed to different COVID-19 variants and understand how genetic mutations in a virus can lead to functional changes. Read more

NGSS Performance Expectations:

MS-LS2-4. Construct an argument supported by empirical evidence that changes to physical or biological components of an ecosystem affect populations.
MS-LS3-1. Develop and use a model to describe why structural changes to genes (mutations) located on chromosomes may affect proteins and may result in harmful, beneficial, or neutral effects to the structure and function of the organism.
HS-LS3-2. Make and defend a claim based on evidence that inheritable genetic variations may result from (1) new genetic combinations through meiosis, (2) viable errors occurring during replication, and/or (3) mutations caused by environmental factors.

Computational Exploration of Protein Function

Science Fair Project Idea

Scientific Method

The DNA in our cells contains our "blueprints," but it's the proteins in our cells that do most of the work. The Human Genome Project has allowed us to start reading the blueprints, but we still don't understand what most of the proteins do. This is a fairly advanced project that explores ways of identifying the function of unknown proteins. Read more

Design 'Y'er Genes

Lesson Plan Grade: 9th-12th

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This lesson introduces students to the relationships between chromosomes, genes, and DNA molecules. Using the example of a strawberry, it also provides activities that clearly show how changes in the DNA of an organism, either naturally or artificially, can cause changes. Read more

NGSS Performance Expectations:

HS-LS3-3. Heredity: Inheritance and Variation of Traits
Apply concepts of statistics and probability to explain the variation and distribution of expressed traits in a population.

High School, Genetics & Genomics Projects, Lessons, Activities (26 results)

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