High School, Medical Biotechnology Projects, Lessons, Activities (Page 2)

The Importance of Making Sure a Drug's Aim Is True

Science Fair Project Idea

Scientific Method

Scientists recently found that some small drugs can stop infection by the deadly Ebola virus in its tracks. Lab researchers found that these drugs bind to a protein that the Ebola virus uses to enter our cells, and this is how infection is prevented. However, this also means that the bound protein no longer functions in our cells. How might these drugs accidentally disrupt important biological processes in our bodies? What other proteins might these drugs bind to? In this science project,… Read more

A Prescription for Success: Drugs & Your Genetics

Science Fair Project Idea

Scientific Method

Have you ever known someone who had a bad reaction to a prescription drug? Although pharmaceutical companies test new drugs on a large number of people to make sure the drug works the way it is supposed to, often a small percentage of people respond differently to the drug. A person's genetics plays a large role in determining his or her response to a given drug. Our genes are made up of hundreds to millions of nucleotides of DNA (deoxyribonucleic acid), the genetic code. If just a single… Read more

Antioxidants

Science Fair Project Idea

Scientific Method

Antioxidants have become very popular in the news lately for their potential health and anti-aging properties. Antioxidants work by preventing oxidation reactions that produce free-radicals which can cause harm to the body. Try testing different vitamins for antioxidant activity. How do vitamins A, B, C, and E compare? Do some vitamins have more antioxidant activity than others? What are some other sources of antioxidants? Try testing extracts from proposed sources of antioxidants like coffee,… Read more

Bio-Engineering: Making and Testing Model Proteins

Lesson Plan Grade: 9th-12th

Students act as if they are biological engineers following the steps of the engineering design process to design and create protein models to replace the defective proteins in a child's body. Jumping off from a basic understanding of DNA and its transcription and translation processes, students learn about the many different proteins types and what happens if protein mutations occur. Then they focus on structural, transport and defense proteins during three challenges… Read more

NGSS Performance Expectations:

HS-LS1-1. Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins which carry out the essential functions of life through systems of specialized cells.
HS-LS1-2. Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms.
HS-ETS1-2. Design a solution to a complex real-world problem by breaking it down into smaller, more manageable problems that can be solved through engineering.
HS-ETS1-3. Evaluate a solution to a complex real-world problem based on prioritized criteria and trade-offs that account for a range of constraints, including cost, safety, reliability, and aesthetics, as well as possible social, cultural, and environmental impacts.

Foldit: Playing a Game While Solving Protein Structures

Science Fair Project Idea

Scientific Method

Unlocking the three-dimensional structure of a protein is crucial to help scientists understand how it functions in our bodies and how it can cause devastating diseases if it becomes disrupted or interacts in the wrong way. However, figuring out the structure of a protein in three-dimensional space can be very challenging. Proteins are the functional units of our cells, and every protein is made up of a long chain of amino acids. Amino acids come in different shapes and sizes, and they have… Read more

How are Biological Medicines Made?

STEM Activity

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Biologic manufacturing is a multi-step process for creating a biological product that can help reduce symptoms or treat a disease. Below is an image of an overview of the drug development process you will be modeling. Figure 1. Overview of the basic steps of the biologic development process modeled in this activity. Read more

How Direct Reprogramming Can Transform One Type of Cell Straight into Another

Science Fair Project Idea

Scientific Method

In the first decade of the 21st century, scientists found ways to make one adult cell type turn into a completely different cell type. This has huge implications for the medical field, including being able to take some cells that a person could spare, such as skin cells or blood cells, and turn them into another cell type that might be much more important for that person to have, such as cells to make a new kidney. How are scientists able to accomplish this amazing feat of "reprogramming" the… Read more

Immunotherapy: How Antibodies Can Be Used to Treat Diseases

Lesson Plan Grade: 8th-12th

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In this lesson, students will do a series of activities to explore the role of antibodies in our immune system. They will also investigate how doctors use monoclonal antibodies as part of immunotherapy to treat diseases like cancer. Read more

Making Model Microfluidic Devices Using JELL-O

Lesson Plan Grade: 9th-12th

Students create large-scale models of microfluidic devices using a process similar to that of the PDMS and plasma bonding that is used in the creation of lab-on-a-chip devices. They use disposable foam plates, plastic bendable straws and gelatin dessert mix. After the molds have hardened overnight, they use plastic syringes to inject their model devices with colored fluid to test various flow rates. From what they learn, students are able to answer the challenge question… Read more

NGSS Performance Expectations:

HS-ETS1-2. Design a solution to a complex real-world problem by breaking it down into smaller, more manageable problems that can be solved through engineering.

Modeling Biologic Manufacturing

Lesson Plan Grade: 6th-9th

In this lesson plan, students will model the complex biologic manufacturing process. First, they will model the cellular expansion process that occurs in a bioreactor. Then, students will lyse the cells to isolate the proteins from the dyed cell debris. Lastly, they will model the advanced filtration process to purify proteins so they can be used as medicines. Read more

NGSS Performance Expectations:

MS-LS1-2. Develop and use a model to describe the function of a cell as a whole and ways the parts of cells contribute to the function.

High School, Medical Biotechnology Projects, Lessons, Activities (23 results)

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