High School, Biotechnology Projects, Lessons, Activities (Page 2)

Making Milk Curdle with Pineapple Enzymes

Science Fair Project Idea

Scientific Method

Have you ever gone to pour yourself a cup of milk and all you get is milk clumps? What happened to the milk is called coagulation, which is the mechanism that occurs when proteins in the milk clump together. While you do not necessarily want this in your milk, without coagulation (or curdling), there would not be any cheese or yogurt, which is why it is a very important process in the food industry. But what makes milk curdle? In this science project you will use pineapple juice to curdle milk… Read more

Column Chromatography: Can you Separate the Dyes in Grape Soda Using Space Sand™?

Science Fair Project Idea

Scientific Method

What color is grape soda? If you pour it into a clear glass you can easily see it is purple, but that is usually not its natural color. Manufacturers add red and blue dye to the soda. The dyes mix together and you get purple soda. What if you wanted to un-mix the dyes, could you? Yes! In a chemistry laboratory, using a technique called column chromatography, you could separate the two dyes again. But what about at home, can you use low-tech supplies to do the same thing? In this science project… Read more

CRISPR Gene Editing of Escherichia coli

Science Fair Project Idea

Scientific Method

Many scientists are currently very excited about CRISPR, as it has the potential to revolutionize gene editing. But what exactly is CRISPR and what does it do? CRISPR is a novel tool in gene editing that allows the modification of genetic DNA at specific target sites in many different organisms. Researchers have high hopes that this technology can, one day, cure genetic diseases, as mutated DNA sequences can easily be corrected. In this project, you will use CRISPR to mutate a DNA sequence… Read more

Expression Cloning

Science Fair Project Idea

Scientific Method

What is expression cloning and how is it used in the biotechnology industry? How are plasmids constructed for use in a bacterial expression system? You can investigate these questions and more using bacterial expression kits meant for high school classes. You will need a laboratory space equipped to grow bacteria and carry out simple molecular biology. A kit with plasmids and bacterial cells to transform are also needed. Here are two possibilities: BioBuilder What a Colorful World Kit … Read more

Genetically Engineer Yeast to be Fluorescent

Science Fair Project Idea

Scientific Method

Can you imagine a glowing loaf of bread? You might not be able to make the whole loaf glow, but you can get baker's yeast to fluoresce! The way to do this is to modify the genetic information of the yeast organism. The technology that is used to do this is called genetic engineering. With genetic engineering, you can insert a fluorescent protein gene from a jellyfish into yeast cells, so they start glowing under blue light! Do this project to see for yourself! Read more

Protein Structure and Function

Science Fair Project Idea

Scientific Method

How a biological system functions is a consequence of the 3-D structures of biological macromolecules like proteins and protein complexes. Proteins can be categorized into different protein families based upon sequence, structure, and function. Typically, proteins in the same family have similar biochemical functions. You can investigate the structure of a protein by using protein databases (Entrez Protein, SwissProt, PDB) and 3-D computational models. You can compare the structures of… Read more

Catalytic RNA and Structure

Science Fair Project Idea

Scientific Method

Some sequences of RNA can catalyze biochemical reactions, much like protein enzymes. These catalytic RNA sequences are called ribozymes. The function of a ribozyme depends upon the primary sequence of the RNA which folds into a 3-D structure. How do different ribozyme sequences fold? You can search for ribozyme sequences using Entrez BLAST (NCBI, 2006). Then you can use a program like MFOLD (http://bioweb.pasteur.fr/seqanal/interfaces/mfold-simple.html) to submit your sequence for an… Read more

CUT! How Does CRISPR Work?

Lesson Plan Grade: 6th-12th

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In this lesson plan, students will take a closer look at the most recent developments in gene editing. Specifically, they will learn about the CRISPR technology using various interactive simulations and other resources. Based on their gained knowledge, students will create a model of the CRISPR-Cas9 components and create a stop-motion animation video of the molecular mechanism of CRISPR-Cas9. Remote learning adaptation: This lesson plan can be conducted remotely. Students can work… Read more

NGSS Performance Expectations:

MS-LS4-5. Gather and synthesize information about technologies that have changed the way humans influence the inheritance of desired traits in organisms.
HS-LS1-1. Construct an explanation, based on evidence, for how the structure of DNA determines the structure of proteins, which carry out the essential functions of life through systems of specialized cells.

No Whey! Milk Protein Content Doesn't Change...Or Does It?

Science Fair Project Idea

Scientific Method

Many people you know probably have an opinion about the kind of milk they like to drink—some like it thin and refreshing, others like it thick and rich. Milk can be bought with different fat concentrations, but other than that, it's all the same. Or is it? This science fair project raises a few interesting questions about the other contents in milk. Do all milk products have the same protein concentrations? Do cows produce different types of milk during different stages of lactation?… Read more

Protein Fingerprinting

Science Fair Project Idea

Scientific Method

First came the Human Genome Project and now (drum roll please) the Human Proteome Project. Confused? Not surprising as the Human Proteome Project has not received the kind of press that the Human Genome Project did. Nonetheless it is a major, and potentially important, scientific undertaking. Just as the genome is the complete set of an organism's DNA, the proteome is all the proteins expressed in an organism. Why study the proteome? It is because proteins are the work horses of biological… Read more

High School, Biotechnology Projects, Lessons, Activities (27 results)

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