Genetic Engineering Projects, Lessons, Activities (Page 2)

Expression Cloning

Science Fair Project Idea

Scientific Method

What is expression cloning and how is it used in the biotechnology industry? How are plasmids constructed for use in a bacterial expression system? You can investigate these questions and more using bacterial expression kits meant for high school classes. You will need a laboratory space equipped to grow bacteria and carry out simple molecular biology. A kit with plasmids and bacterial cells to transform are also needed. Here are two possibilities: BioBuilder What a Colorful World Kit … Read more

Genetically Engineer Yeast to be Fluorescent

Science Fair Project Idea

Scientific Method

Can you imagine a glowing loaf of bread? You might not be able to make the whole loaf glow, but you can get baker's yeast to fluoresce! The way to do this is to modify the genetic information of the yeast organism. The technology that is used to do this is called genetic engineering. With genetic engineering, you can insert a fluorescent protein gene from a jellyfish into yeast cells, so they start glowing under blue light! Do this project to see for yourself! Read more

CUT! How Does CRISPR Work?

Lesson Plan Grade: 6th-12th

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In this lesson plan, students will take a closer look at the most recent developments in gene editing. Specifically, they will learn about the CRISPR technology using various interactive simulations and other resources. Based on their gained knowledge, students will create a model of the CRISPR-Cas9 components and create a stop-motion animation video of the molecular mechanism of CRISPR-Cas9. Remote learning adaptation: This lesson plan can be conducted remotely. Students can work… Read more

NGSS Performance Expectations:

MS-LS4-5. Gather and synthesize information about technologies that have changed the way humans influence the inheritance of desired traits in organisms.
HS-LS1-1. Construct an explanation, based on evidence, for how the structure of DNA determines the structure of proteins, which carry out the essential functions of life through systems of specialized cells.

How Direct Reprogramming Can Transform One Type of Cell Straight into Another

Science Fair Project Idea

Scientific Method

In the first decade of the 21st century, scientists found ways to make one adult cell type turn into a completely different cell type. This has huge implications for the medical field, including being able to take some cells that a person could spare, such as skin cells or blood cells, and turn them into another cell type that might be much more important for that person to have, such as cells to make a new kidney. How are scientists able to accomplish this amazing feat of "reprogramming" the… Read more

Molecular Scissors

Science Fair Project Idea

Scientific Method

Ever used a pair of molecular scissors? Restriction enzymes are molecular scissors that cut DNA into pieces. Find out which enzymes will cut, and where by making a restriction map. Then you can figure out what will happen if you change the sequence of the DNA. Will the same enzymes still cut the new DNA sequence? Read more

Using Synthetic DNA as a Secret Barcode

Science Fair Project Idea

Scientific Method

How would you secretly mark a bank robber during a robbery? What could you do to ensure that the ethically grown cotton you grew and shipped off for weaving and garment making was used to make the shipment of shirts you received weeks later? When we want to tag and track something, we often use a barcode. From grocery store foods to FedEx packages, barcodes are a way of tagging and identifying items. The fact that barcodes can be unique and are easy to read are key features. Not all things… Read more

Preventing the Zombie Apocalypse- Making Gene Therapy Safe!

Lesson Plan Grade: 9th-12th

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Students become biomedical engineers and create model viruses for use in therapeutic applications, such as gene therapy. In constructing their models, students carefully plan for side effects and modify a virus that can be used to safely to deliver gene therapy. This process involves taking a "wild type" (or unmodified) virus so it can target a specific area of the body.Engineering Connection Genetic engineering is the artificial manipulation, modification, and… Read more

NGSS Performance Expectations:

HS-ETS1-2. Design a solution to a complex real-world problem by breaking it down into smaller, more manageable problems that can be solved through engineering.

Bacteria Transformation

Lesson Plan Grade: 9th-12th

Students construct paper recombinant plasmids to simulate the methods genetic engineers use to create modified bacteria. They learn what role enzymes, DNA and genes play in the modification of organisms. For the particular model they work on, they isolate a mammal insulin gene and combine it with a bacteria's gene sequence (plasmid DNA) for production of the protein insulin.Engineering Connection Bacteria are the most common organisms modified by genetic engineers due to… Read more

NGSS Performance Expectations:

HS-LS1-1. Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins which carry out the essential functions of life through systems of specialized cells.

Bacterial Adaptations and Their Application in Genetic Engineering

Lesson Plan Grade: 6th-8th

Students explore adaptations by researching how animals, plants, and bacteria change based on their environment. They grow bacterial colonies in various environments and hypothesize how each environment will affect the cell culture size and color. After a day of pre-growth, the culture is spun down in a centrifuge and the cell pellet is analyzed. Finally, students research bacteria adaptations that allow them to survive in extreme environments then brainstorm how the… Read more

NGSS Performance Expectations:

MS-LS1-5. Construct a scientific explanation based on evidence for how environmental and genetic factors influence the growth of organisms.

Genetic Engineering Projects, Lessons, Activities (19 results)

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