Science Buddies' twelfth grade science projects are the perfect way for twelfth grade students to have fun exploring science, technology, engineering, and math (STEM). Our twelfth grade projects are written and tested by scientists and are specifically created for use by students in the twelfth grade. Students can choose to follow the science experiment as written or put their own spin on the project.

For a personalized list of science projects, twelfth graders can use the Science Buddies Topic Selection Wizard. The wizard asks students to respond to a series of simple statements and then uses their answers to recommend age-appropriate projects that fit their interests.

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Science Fair Project Idea
Over time, viruses evolve. Their evolution is influenced by both neutral drift, the natural mutation rate of the virus, and selective pressure from the hosts' immune systems. Scientists study a virus's genomic evolution—the changes at the nucleotide and amino acid level—to better understand how the virus is spreading and the clinical implications. You can use public databases and tools to do the same type of tracking and analysis of COVID-19 that scientists around the world do. … Read more
Science Fair Project Idea
"Flu season" is something we deal with every winter. Cyclical or seasonal outbreaks of an infectious disease can occur for a variety of reasons, such as seasonal changes in host behavior (for example, more people staying indoors), the seasonal abundance of disease carriers (for example, mosquitos), and many others. Another factor that can play a role in cyclical outbreaks occurs when the natural immunity to a disease has a short duration. This enables each individual in the population to… Read more
Science Fair Project Idea
Are you interested in the technical and ethical aspects of genetic screening, forensic science, and DNA fingerprinting? Scientists use different forms of a gene, called alleles, to differentiate between two fingerprints. One such sequence used in human DNA fingerprinting is the Alu repeat (a 300 base pair repetitive sequence of DNA) on chromosome 16. During evolutionary time, up to 1 million copies of the Alu repeat have become randomly inserted throughout the human genome. Within a specific… Read more
Science Fair Project Idea
We use passwords every day for our email and other computer accounts. How secure is the password that you use? How hard would it be for someone to guess your password? How hard is it to write a computer program to guess a password? You can see for yourself by writing a simple password guesser in the computer language Python. We will get you started with some ideas, a little sample code, and a few passwords for your computer program to try and guess. Read more
Science Fair Project Idea
You may have seen police investigators on TV spraying a crime scene with a liquid that glows blue if there is any blood present. Luminol is the chemical which causes the glowing. In this chemistry science fair project, you will investigate what factors make this interesting molecule "light up." Read more
Science Fair Project Idea
Many scientists are currently very excited about CRISPR, as it has the potential to revolutionize gene editing. But what exactly is CRISPR and what does it do? CRISPR is a novel tool in gene editing that allows the modification of genetic DNA at specific target sites in many different organisms. Researchers have high hopes that this technology can, one day, cure genetic diseases, as mutated DNA sequences can easily be corrected. In this project, you will use CRISPR to mutate a DNA sequence… Read more
Science Fair Project Idea
The first man-made satellite, the Sputnik 1, was launched in 1957. As of late 2020, more than 2,600 man-made satellites orbit Earth, with a little over 70% of them in low Earth orbit. If you would like to delve into how satellites and their sensors are configured, or into how their orbits are planned—and do not shy away from a little programming—this project is for you! With the help of FreeFlyer®—powerful software that allows you to simulate satellite orbit and… Read more
Science Fair Project Idea
When you have your X-rays taken at the dentist's or doctor's office, do you ever wonder how the X-ray machine works? Or better yet, how you could make one yourself to use for experiments? This how-to guide provides detailed instructions for high school students and adult do-it-yourself (DIY) enthusiasts to construct and use a homemade X-ray machine safely. Read more
Science Fair Project Idea
Maple syrup on pancakes, ripe bananas, and soft drinks are all foods that are tasty to us because of the sugar in them. But did you know there are different kinds of sugar? One food can have multiple kinds of sugar in it, and our bodies actually process the different types of sugars differently. In this science project, you will measure the concentration of two sugars—glucose and sucrose—in different foods, and investigate how sucrose is converted into glucose with the help… Read more
Science Fair Project Idea
Have you ever wondered how your clothes get their color? Dyeing textiles is a very complicated process and involves a lot of chemistry. Not only are the properties of the dye and fabric important, but the dyeing conditions also have to be exactly right to get optimal color adsorption. Curious about how it works? In this science project, you will color wool with Kool-Aid® and explore the chemistry of dyeing. Read more
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Free science fair projects.