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Middle School, Microbiology Projects, Lessons, Activities (25 results)

Microorganisms are all around us, with an amazing diversity of adaptations. They were the first life on Earth, and their relatively recent discovery in extreme environments—like hot springs, ocean vents, and polar ice—illustrates how tenaciously they've evolved and survived. Microbiology gives us insights into evolution, disease, and even the mechanisms of our own cells.

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Measuring Antimicrobial Effectiveness with Zones of Inhibition
Science Fair Project Idea
Scientific Method
Have you heard that garlic powder is supposed to inhibit the growth of bacteria? Which do you think would make a better disinfectant: a solution of garlic powder or a solution of bleach? This project shows you a straightforward way to compare the effectiveness of different disinfectants (or other antimicrobial agents), by measuring zones of inhibition on a culture plate. Read more
Make Your Own Hand Sanitizer
STEM Activity
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34 reviews
Did you ever wonder what hand sanitizer is made of, or how you can efficiently disinfect your hands or other frequently touched surfaces like doorknobs? Handwashing is still the best way to keep your hands clean, but hand sanitizer is a great alternative for situations where clean water and soap are not available, and you can even use it to disinfect surfaces! Intrigued—try out making a hand sanitizer yourself! Read more
Yeast Reproduction in Sugar Substitutes
Science Fair Project Idea
Scientific Method
There is nothing quite like the smell of fresh-baked bread to make your mouth water! As any baker can tell you, you cannot bake bread without yeast. Yeast actually eat sugar so that they can reproduce and make more yeast, and make bread dough rise. But can they use sugar substitutes to do this? In this science project you will get to investigate how well yeast grow with sugar substitutes as a food source. Pass the butter, please! Read more
How Do Bacteria Produce Power in a Microbial Fuel Cell?
Science Fair Project Idea
Scientific Method
Bacteria are powerful little creatures. They can dispose of contaminants, make us sick and did you know they can even generate electricity? In devices, called microbial fuel cells (MFC) they can extract electrons from their food sources such as organic materials and feed them into an electrical circuit to generate power. This way they can even turn plain soil into a source of energy! Does it matter though what kind of food the bacteria "eat"? Find out how bacteria grow in a microbial fuel cell… Read more
Do Antibiotics Change Your Gut Microbiome?
Science Fair Project Idea
Scientific Method
There are thousands of bacteria in your gut that help you digest your food, recover important nutrients, and maintain your health. What happens to those bacteria when you take antibiotics? In this science project you will find out by accessing and analyzing a real data set of the gut microbiome (bacteria and other microbes) from healthy adults before and after they are given antibiotics. Read more
Germ Invasion
Science Fair Project Idea
Scientific Method
Microbes are everywhere in our environment, but for the most part they escape our notice. This project shows you how to safely culture and study common bacteria from your everyday surroundings. Read more
Grow Vegan Kombucha Leather
Science Fair Project Idea
Scientific Method
Do you love the look and feel of leather? Many luxury items like handbags, belts, wallets, and coats are made from leather. What if you could make your own vegan leather in a few weeks? Could it be a greener, more sustainable option than cowhide leather? In this science project, you will grow your own vegan leather from kombucha and see how different growing conditions affect the resulting leather. Read more
How Do Viruses React To Soap?
STEM Activity
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64 reviews
Have you ever wondered why we wash our hands with water and soap to get rid of bacteria and viruses? Good hand hygiene becomes especially important during viral outbreaks such as the COVID-19 pandemic! The CDC (Center for Disease Control) recommendations for handwashing say to scrub your hands for at least 20 seconds with water and soap. But how does soap kill viruses such as SARS-COV-2? In this activity, you will find out by experimenting with models of different virus types to see how they… Read more
Learn How to Disinfect Contaminated Water
Science Fair Project Idea
Scientific Method
Have you ever thought about how fortunate you are to have safe and clean water coming out of your faucet? Many people in undeveloped nations don't have this luxury. But does that mean they can't have clean water at all? Is there an inexpensive way they could use to make their own clean water? In this microbiology science fair project, you will investigate whether or not sunlight can disinfect contaminated water. Read more
Small, Tiny, Invisible: How Big Is a Virus?
STEM Activity
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30 reviews
Have you ever seen a real virus? Probably not—they are so tiny that it is impossible to see them with your naked eyes. But how big or small are viruses really? The coronavirus Sars-Cov-2, which causes COVID-19, is about 120 nanometers in size. One nanometer is equal to one billionth of a meter! How many of these tiny coronaviruses do you think can you line up inside a pencil dot? In this activity, you will find out by creating a scale model that allows you to compare the size of many… Read more
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