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High School Lesson Plans (70 results)

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Model the Chances of Getting an Autoimmune Disease
Lesson Plan Grade: 9th-12th
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Can genetic or environmental factors affect our chances of getting a certain disease? In this activity, your students will model how an existing predisposition can impact the probability of developing an autoimmune disease using dice and M&M's® candy! Read more
NGSS Performance Expectations:
  • HS-LS3-3. Apply concepts of statistics and probability to explain the variation and distribution of expressed traits in a population.
Modeling Biologic Manufacturing
Lesson Plan Grade: 6th-9th
In this lesson plan, students will model the complex biologic manufacturing process. First, they will model the cellular expansion process that occurs in a bioreactor. Then, students will lyse the cells to isolate the proteins from the dyed cell debris. Lastly, they will model the advanced filtration process to purify proteins so they can be used as medicines. Read more
NGSS Performance Expectations:
  • MS-LS1-2. Develop and use a model to describe the function of a cell as a whole and ways the parts of cells contribute to the function.
Molecular Models and 3D Printing
Lesson Plan Grade: 9th-12th
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Students are challenged to use computer-aided design (CAD) software to create "complete" 3D-printed molecule models that take into consideration bond angles and lone-pair positioning. To begin, they explore two interactive digital simulations: "build a molecule" and "molecule shapes." This aids them in comparing and contrasting existing molecular modeling approaches—ball-and-stick, space-filling, and valence shell electron pair repulsion (VSEPR)—so as to… Read more
NGSS Performance Expectations:
  • HS-PS1-1. Use the periodic table as a model to predict the relative properties of elements based on the patterns of electrons in the outermost energy level of atoms.
Nanotechnology in Action: Organic Electronics
Lesson Plan Grade: 9th-12th
This activity focuses on the use of graphene in organic fibers, and their applications in organic electronics, e-textiles and wearable technologies. Students learn about the properties of graphene—unique form of carbon—and how graphene-based fibers are fabricated, how to measure resistance, how to calculate resistivity, and how a material changes its electrical properties. Students also learn about the importance of defining design parameters, which is an… Read more
Ping Pong Pickup Challenge for Grades 9-12
Lesson Plan Grade: 9th-12th
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In this fun engineering lesson plan, your students will build devices from paper, tape, string, and paper clips to pick up and retrieve a ping pong ball. The challenge is to pick up the ball from as far away as possible! Elementary school and middle school versions of this lesson plan are also available. The 2023 competition is over, but you can see what students built and learn about the winners on the 2023 Engineering Challenge summary page. Read more
NGSS Performance Expectations:
  • High School - Science & Engineering Practices
Preventing Outbreaks with Herd Immunity
Lesson Plan Grade: 6th-12th
What is herd immunity, how is it achieved, and what impact does it have on outbreaks? Students will explore these questions and more in this lesson plan. They will then use SimPandemic, a free online tool, to model different levels of viral immunity in communities to understand how a population can reach the herd immunity threshold and the impacts that has on individuals and populations during a COVID-19 outbreak. Remote learning adaptation: This lesson plan can be conducted remotely. … Read more
NGSS Performance Expectations:
  • MS-LS2-4. Construct an argument supported by empirical evidence that changes to physical or biological components of an ecosystem affect populations.
  • HS-LS2-8. Evaluate evidence for the role of group behavior on individual and species' chances to survive and reproduce.
Protecting Nature with Technology
Lesson Plan Grade: 9th-12th
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You might have read about the negative impacts modern human civilization has had on the environment, like pollution, deforestation, and extinction of animal species. How can we use modern technology to help protect the environment? In this project-based lesson students will design an electronic circuit that can measure something in the environment like water quality and light pollution, and develop a plan for how their circuits could be used to solve a real-world problem. Read more
NGSS Performance Expectations:
  • HS-ESS3-4. Evaluate or refine a technological solution that reduces impacts of human activities on natural systems.
Recycling PLA Plastic using Green Chemistry
Lesson Plan Grade: 9th-12th
Educational Goal To understand: How polylactic acid (PLA) plastic is an example of green chemistry technology particularly pollution prevention and designing safer chemicals Student Objectives Students will: Learn about renewable "corn" plastic is made from polylactic acid Recycle the polylactic acid cup into a new product: a cleaning solution Conduct a saponification reaction Analyze PLA against the 12 principles of green chemistry (Optional) Verify the contents of their… Read more
Rocket Catcher Challenge for Grades 9-12
Lesson Plan Grade: 9th-12th
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In this fun engineering lesson plan, your students will build a rocket-catching device to help a falling rocket land vertically without crashing, using simple and readily-available materials. Elementary and middle school versions of this lesson plan are also available. This lesson was part of the 2025 Science Buddies Engineering Challenge. Read more
NGSS Performance Expectations:
  • High School - Science & Engineering Practices
Studying Evolution with Digital Organisms
Lesson Plan Grade: 9th-12th
Students observe natural selection in action and investigate the underlying mechanism, including random mutation and differential fitness based on environmental characteristics. They do this through use of the free AVIDA-ED digital evolution software application.Engineering Connection Computer scientists and engineers work together to create software and hardware to model complex systems and create new technologies. The digital evolution software, Avida, was created by a… Read more
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