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Middle School, Genetics & Genomics Projects, Lessons, Activities (17 results)

What traits are heritable? How different is your DNA from a frog's, a mouse's or even your relative's? Can your genes tell doctors what is the right dose of a medicine for your body? These are the types of questions scientists are answering with genetics and genomics. By studying individual genes as well as genomes, the whole set of DNA belonging to an organism, scientists hope to get a more complete understanding of how our bodies work and develop better disease treatments.

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Are Fingerprint Patterns Inherited?
Science Fair Project Idea
Scientific Method
Have you ever looked at two girls and thought they looked so similar that they must be sisters? What about a father and his son — have you ever seen a boy who looked just like how his father did when he was younger? We can often tell that two people are related because they appear to have several similar physical traits. This is because children receive half of their DNA — their genetic blueprints — from each parent. What about fingerprints — are they an inherited trait?… Read more
Investigate Alien Genetics
STEM Activity
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123 reviews
Have you ever wondered why biological siblings look so much alike? Why do they often share physical traits, such as hair color or eye color? It all has to do with their genes. Genes are passed on from parents to their offspring. This means that you share some of the same genes with your biological parents and siblings! In this activity, you will use an alien model to demonstrate how genes or physical traits are passed on from parents to their offspring. How similar will your alien siblings look? Read more
Paper DNA Model
STEM Activity
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Ever wondered how DNA, the genetic blueprint of a life-form, can encode and pass on the information on how to grow and maintain that life-form? Just like a cookbook contains a complete recipe for a dish, DNA stores the recipe for the life of an organism. Although each human has a unique DNA sequence, the DNA in all of us is about 99.9% identical! In this activity, you will make a model for a short section of DNA—enough to get a sense of what DNA is like and how it encodes life. Read more
Pedigree Analysis: A Family Tree of Traits
Science Fair Project Idea
Scientific Method
Some characteristics, like the shape of your hairline or whether your earlobes are attached or detached, are inherited from your parents. In this science project you will see how writing these characteristics onto a family tree can help you determine how they are inherited Read more
Drugs & Genetics: Why Do Some People Respond to Drugs Differently than Others?
Science Fair Project Idea
Scientific Method
In a survey conducted from 2007 to 2010, the U.S. Centers for Disease Control and Prevention reported that about 49% of people in the United States had taken at least one prescription drug during the past month, and about 22% of people had taken three or more prescription drugs. People are prescribed drugs all the time, but prescriptions can be dangerous because people can have different responses to drugs. These responses largely have to do with genetic mutations. Why are some genetic… Read more
From Genes to Genetic Diseases: What Kinds of Mutations Matter?
Science Fair Project Idea
Scientific Method
Our genes are made up of hundreds to millions of building blocks, called DNA nucleotides, and if just a single nucleotide of DNA becomes mutated it might cause a devastating genetic disease. But sometimes a mutation actually does no damage. What kinds of mutations have to occur to cause a genetic disease? In this science project, you will explore online genetic databases to identify how a mutation in a gene can result in a dysfunctional protein, and how other mutations may have no effect at all. Read more
Investigate Alien Genetics
Lesson Plan Grade: 6th-8th
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In this lesson, students will model how traits are passed on from parents to their offspring by creating baby aliens based on their parents' traits. As students compare the physical features of their alien families, they will be able to make the connection between an organism's genotype and phenotype. Students will also learn the difference between dominant and recessive traits. Read more
NGSS Performance Expectations:
  • MS-LS3-2. Develop and use a model to describe why asexual reproduction results in offspring with identical genetic information and sexual reproduction results in offspring with genetic variation.
CUT! How Does CRISPR Work?
Lesson Plan Grade: 6th-12th
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In this lesson plan, students will take a closer look at the most recent developments in gene editing. Specifically, they will learn about the CRISPR technology using various interactive simulations and other resources. Based on their gained knowledge, students will create a model of the CRISPR-Cas9 components and create a stop-motion animation video of the molecular mechanism of CRISPR-Cas9. Remote learning adaptation: This lesson plan can be conducted remotely. Students can work… Read more
NGSS Performance Expectations:
  • MS-LS4-5. Gather and synthesize information about technologies that have changed the way humans influence the inheritance of desired traits in organisms.
  • HS-LS1-1. Construct an explanation, based on evidence, for how the structure of DNA determines the structure of proteins, which carry out the essential functions of life through systems of specialized cells.
How Much DNA Can You Pack into a Cell?
Science Fair Project Idea
Scientific Method
Have you ever tried to pack a suitcase? If so, you know that no matter how hard you try, there is a limit to the amount you can cram in, which means if you have more stuff, you need a bigger suitcase! Do you think the same principle applies to DNA in a cell? Does an animal with a bigger genome need a larger cell nucleus to store its DNA? Try this science project and find out! Read more
What is the Woolly Mammoth's Closest Living Relative?
Science Fair Project Idea
Scientific Method
Woolly mammoths shook the ground of ice-age tundras for millennia, living next to saber tooth tigers and prehistoric man. Although they have been extinct for thousands of years, scientists continue to learn more and more about this mighty animal. Some of the most exciting new research is being produced by looking at DNA extracted from the hair and bones of woolly mammoths entombed in ice. In this genomics science fair project, you will use bioinformatics tools to determine the woolly mammoth's… Read more
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