Good Health and Well-Being, Biotechnology Science Projects (Page 2)

DNA Fingerprinting

Science Fair Project Idea

Scientific Method

Are you interested in the technical and ethical aspects of genetic screening, forensic science, and DNA fingerprinting? Scientists use different forms of a gene, called alleles, to differentiate between two fingerprints. One such sequence used in human DNA fingerprinting is the Alu repeat (a 300 base pair repetitive sequence of DNA) on chromosome 16. During evolutionary time, up to 1 million copies of the Alu repeat have become randomly inserted throughout the human genome. Within a specific… Read more

Protein Structure and Function

Science Fair Project Idea

Scientific Method

How a biological system functions is a consequence of the 3-D structures of biological macromolecules like proteins and protein complexes. Proteins can be categorized into different protein families based upon sequence, structure, and function. Typically, proteins in the same family have similar biochemical functions. You can investigate the structure of a protein by using protein databases (Entrez Protein, SwissProt, PDB) and 3-D computational models. You can compare the structures of… Read more

CRISPR Gene Editing of Escherichia coli

Science Fair Project Idea

Scientific Method

Many scientists are currently very excited about CRISPR, as it has the potential to revolutionize gene editing. But what exactly is CRISPR and what does it do? CRISPR is a novel tool in gene editing that allows the modification of genetic DNA at specific target sites in many different organisms. Researchers have high hopes that this technology can, one day, cure genetic diseases, as mutated DNA sequences can easily be corrected. In this project, you will use CRISPR to mutate a DNA sequence… Read more

Separating Glitter with a Homemade Centrifuge

Science Fair Project Idea

Scientific Method

It is fun to shake up a snow globe and watch the "snow" slowly fall. You can imagine that if the snow fell down very quickly it would be disappointing. But there are times when scientists in a laboratory want this to happen. Scientists use samples that have liquid mixed with small, solid pieces (like the inside of a snow globe), and they need all of the solid pieces in a clump, separated from the liquid. Instead of waiting for the pieces to slowly fall out of the liquid, scientists speed up… Read more

A Magnetic Primer Designer

Science Fair Project Idea

Scientific Method

How do scientists "copy" DNA? They use a process called the Polymerase Chain Reaction, or PCR. The key to making this process work is having a short piece of DNA, called a primer, that will stick to the larger piece of DNA you want to copy, called a template. In this science project, you will test how the number of matches and mismatches in a primer will affect its ability to stick, or anneal, to the DNA template during PCR. Read more

Catalytic RNA and Structure

Science Fair Project Idea

Scientific Method

Some sequences of RNA can catalyze biochemical reactions, much like protein enzymes. These catalytic RNA sequences are called ribozymes. The function of a ribozyme depends upon the primary sequence of the RNA which folds into a 3-D structure. How do different ribozyme sequences fold? You can search for ribozyme sequences using Entrez BLAST (NCBI, 2006). Then you can use a program like MFOLD (http://bioweb.pasteur.fr/seqanal/interfaces/mfold-simple.html) to submit your sequence for an… Read more

Protein Fingerprinting

Science Fair Project Idea

Scientific Method

First came the Human Genome Project and now (drum roll please) the Human Proteome Project. Confused? Not surprising as the Human Proteome Project has not received the kind of press that the Human Genome Project did. Nonetheless it is a major, and potentially important, scientific undertaking. Just as the genome is the complete set of an organism's DNA, the proteome is all the proteins expressed in an organism. Why study the proteome? It is because proteins are the work horses of biological… Read more

No Whey! Milk Protein Content Doesn't Change...Or Does It?

Science Fair Project Idea

Scientific Method

Many people you know probably have an opinion about the kind of milk they like to drink—some like it thin and refreshing, others like it thick and rich. Milk can be bought with different fat concentrations, but other than that, it's all the same. Or is it? This science fair project raises a few interesting questions about the other contents in milk. Do all milk products have the same protein concentrations? Do cows produce different types of milk during different stages of lactation?… Read more

Purification Strategies

Science Fair Project Idea

Scientific Method

In order to study individual biochemical compounds like proteins, DNA, or RNA, biochemists need to know how to purify these components from a complex mixture. This is especially important for biotechnology and pharmaceutical industries, which sell purified biochemicals as reagents or drugs to consumers. Do an experiment to purify DNA, RNA, or protein from a complex mixture (for purifying DNA, see the Science Buddies project Extracting Onion DNA). The source of the material can be a cell… Read more

Solubility of Proteins

Science Fair Project Idea

Scientific Method

Some proteins are soluble in aqueous solutions and some are not. Insoluble proteins can be a problem because the proteins can form large aggregates in solution which are difficult to purify, crystallize, and use in experiments. Compare the amino acid sequence and 3-D structures of some soluble and insoluble proteins (Berman, 2000). Is the structure polar or non-polar, and how might this affect solubility? How do detergents make an insoluble protein more soluble? Investigate how this… Read more

Good Health and Well-Being, Biotechnology Science Projects (20 results)

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